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The year is 2016 and the setting is the United States of America.
Jumbo jet flight number 326 flying at an altitude of 35,000 feet gets hijacked by an unknown group of individuals. They have used the muscle relaxant Vecuronium Bromide - a chemical that could be lethal if inhaled excessively. Among the 517 passengers who are taken hostage in the cabin filled with the potentially lethal gas is Senator Hach, a man rumored to become the next United States President.
In the meantime on a small island called Lobito, a part of the South African republic Moloni stands the Lobito Physics and Chemistry Laboratory compound. It is guarded by a brutal, ruthless and mysterious armed force. A solitary man is lurking near this heavily fortified base.
His name is Solid Snake.
The hijackers of flight 326 are making only one request - the handing over of "Pythagoras". The United States security officials work on identifying the hijackers and determining what the mysterious "Pythagoras" is and soon finds out what it is that connects the demands and the Lobito Laboratory. "Pythagoras" is the name of a project on which research is conducted on Lobito Island.
The Moloni government is reluctant to cooperate, saying that it does not want any interference in its domestic affairs. Losing its patience, the US government sends in its special forces operation HRT, but the soldiers are attacked by the armed force on the island. All communications are lost.
Despite the Moloni governments best efforts, the contents of the classified research at the Lobito Physics and Chemistry Laboratory are about to be revealed.
With things in a deadlock, the US government decides to make use of its last resort -- the already retired legendary mercenary Solid Snake. There is not much time left till the time limit. Solid Snake's new battle begins at the secret lab on the mysterious and enchanting island.
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